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[Effective treatment with tranexamic acid for chronic disseminated intravascular coagulation associated with aortic

Takahiro Tsuji1, Keiko Morikawa, Taichi Hirano

  • 1Division of Hematology and Oncology, Kumamoto City Hospital.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|September 6, 2013
PubMed

An 82-year-old female with a history of aortic dissection was admitted to our hospital for evaluation of thrombocytopenia and a bleeding tendency. Blood coagulation test data demonstrated that the patient had disseminated intravascular coagulation (DIC) secondary to aortic dissection. We initiated anti-fibrinolytic therapy with tranexamic acid. After this anti-fibrinolytic therapy, thrombocytopenia and the levels of fibrinogen and fibrinogen degradation products improved. In addition, we reviewed 7 other patients who were treated with tranexamic acid for DIC associated with aortic dissection. Anti-fibrinolytic therapy with tranexamic acid is effective for treating DIC secondary to aortic dissection.

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