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Updated: May 8, 2026

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse
Published on: October 25, 2024
Th17 memory cells: live long and proliferate
11.Dept. of Medicine, Division of Rheumatology and Clinical Immunology, BST S719, 3500 Terrace St., Pittsburgh, PA 15261, USA. mmcgeach@pitt.edu.
Abstract:
The development of immune memory is a double-edged sword, helping to maintain health by preventing repeated infections but also driving chronic inflammation when dysregulated. Th17 cells are now well-known as major drivers of autoimmune disease but also play roles in protective immune responses against pathogens. This mini-review will focus on the recent evidence for long-lived, robust Th17 memory cell populations in mouse models and humans, and their functional roles in mediating host protection and chronic disease states.
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