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Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
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Time-resolved diffuse optical tomography using fast-gated single-photon avalanche diodes.

Agathe Puszka1, Laura Di Sieno, Alberto Dalla Mora

  • 1CEA-LETI, Minatec Campus, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France.

Biomedical Optics Express
|September 7, 2013
PubMed
Summary
This summary is machine-generated.

This study shows fast-gated single-photon avalanche diode (SPAD) technology improves deep tissue imaging in diffuse optical tomography (DOT). Gated mode SPADs enhance detection and localization of absorbing targets in turbid media.

Keywords:
(030.5260) Photon counting(170.3010) Image reconstruction techniques(170.6920) Time-resolved imaging(170.6960) Tomography(170.7050) Turbid media(230.5170) Photodiodes

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Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Photonics

Background:

  • Diffuse Optical Tomography (DOT) is a promising non-invasive imaging technique.
  • Time-resolved DOT enhances imaging depth and resolution.
  • Fast detection systems are crucial for efficient time-resolved measurements.

Purpose of the Study:

  • To evaluate the performance of a fast-gated single-photon avalanche diode (SPAD) for reflectance DOT.
  • To compare gated vs. non-gated SPAD modes for detecting deep absorbing inclusions.
  • To assess the clinical relevance of time-resolved DOT at small interfiber distances.

Main Methods:

  • Experimental setup utilizing a fast-gated SPAD and time-correlated single-photon counting.
  • Application of the Mellin-Laplace transform for processing time-resolved data.
  • Phantom studies with embedded absorbing inclusions at varying interfiber distances (5 and 15 mm).

Main Results:

  • The gated SPAD mode demonstrated superior detection and localization of deep absorbing inclusions compared to the non-gated mode.
  • Improved performance was observed for a given acquisition time.
  • Effective imaging of inclusions was achieved even at small interfiber distances (5 mm).

Conclusions:

  • Fast-gated SPADs significantly enhance the depth sensitivity of reflectance DOT.
  • Gated mode operation improves the detection and localization capabilities for embedded absorbers.
  • Time-resolved DOT with gated SPADs shows increased clinical relevance for superficial tissue imaging.