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Published on: July 22, 2014
A second generation MRI contrast agent for imaging zinc ions in vivo.
Luis M De León-Rodríguez1, Angelo J M Lubag, Jorge A López
1Departamento de Química, Universidad de Guanajuato, Cerro de la Venada s/n, Guanajuato, Gto., C.P. 36040, México.
Abstract:
A Zn2+ specific GdDOTA derivative containing two bis-(3-pyrazolyl) units was prepared and characterized. Unlike a previously reported Zn2+ binding agent, the new agent binds to human albumin both in the presence and absence of Zn2+.
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