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Anthracene-bisphosphonate based novel fluorescent organic nanoparticles explored as apoptosis inducers of cancer

Malay Pramanik1, Nabanita Chatterjee, Subhadip Das

  • 1Department of Materials Science, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India. msab@iacs.res.in.

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Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...