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Updated: May 8, 2026
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MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
Published on: October 7, 2025
An ultrasensitive homogeneous chemiluminescent assay for microRNAs
Huimin Deng1, Yuqian Ren, Wei Shen
1Department of Chemistry, National University of Singapore, Singapore 117543. chmgaoz@nus.edu.sg.
Chemical Communications (Cambridge, England)
|September 11, 2013
Abstract:
On the basis of a dual-amplification strategy, microRNA (miRNA) hybridization amplification by a duplex-specific nuclease (DSN) and signal amplification by a DNAzyme, a highly sensitive and selective homogeneous miRNA assay is developed. By leveraging on the cumulative and selective nature of the DSN amplification process, excellent sensitivity and selectivity are accomplished.
