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Parkinson's Disease: Treatment

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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
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Related Experiment Video

Updated: May 8, 2026

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease

Published on: October 4, 2021

Levodopa-responsive benign tremulous parkinsonism.

Osamu Kano¹, Shinichi Okonogi, Sayori Hanashiro

¹Department of Neurology, Toho University Omori Medical Center, Tokyo, Japan.

Case Reports in Neurology

|September 11, 2013

Summary

Benign tremulous parkinsonism (BTP) can present as levodopa-responsive Parkinson's disease (PD). This case study highlights a patient with tremor-dominant PD that responded well to medication, showing limited progression.

Keywords:

Benign tremulous parkinsonism Essential tremor Levodopa Parkinson's disease Rest tremor

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Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Published on: October 14, 2021

Related Experiment Videos

Last Updated: May 8, 2026

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease

Published on: October 4, 2021

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Published on: October 14, 2021

Area of Science:

Neurology
Movement Disorders

Background:

Benign tremulous parkinsonism (BTP) is typically defined as mild, levodopa-resistant parkinsonism.
Characterized by tremor dominance and limited disease progression.

Observation:

A 56-year-old woman presented with a 2-year history of rest tremor and slow finger tapping.
Initial diagnosis was Parkinson's disease (PD), treated effectively with levodopa/carbidopa.
Recurrent tremor at age 61 responded to levodopa/carbidopa and selegiline.

Findings:

The patient's tremor-dominant parkinsonism was responsive to levodopa.
Disease progression was minimal over 11 years since symptom onset.
This presentation challenges the traditional definition of BTP.

Implications:

This case expands the clinical characterization of benign tremulous parkinsonism.
Suggests that levodopa-responsive Parkinson's disease can fall under the BTP spectrum.
Highlights the importance of considering medication response in diagnosing tremor-dominant syndromes.