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Updated: May 8, 2026

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies
Published on: January 7, 2019
Human immunodeficiency virus - associated lymphomas: a neglected domain
Nagesh Tatero Sirsath1, Lakshmaiah Kuntejowdahalli Channaviriappa, Lokesh Kadabur Nagendrappa
1Department of Medical Oncology, Kidwai Memorial Institute of Oncology, M.H. Mari Gowda Road, Bangalore, Karnataka, India.
HIV-associated lymphoma treatment is effective in India. Over half of treated patients achieved lymphoma remission with a median follow-up of 18 months, indicating treatment should be encouraged.
Area of Science:
- Oncology
- Infectious Diseases
- Epidemiology
Background:
- HIV-associated lymphoma presents a significant public health challenge.
- Limited epidemiological data exists for HIV-associated lymphoma in India.
Purpose of the Study:
- To analyze the epidemiological and clinical characteristics of HIV-associated lymphoma.
- To evaluate treatment outcomes in a South Indian tertiary cancer center.
Main Methods:
- Retrospective observational study of 44 HIV-associated lymphoma patients from 2008-2012.
- Analysis of patient demographics, CD4 counts, lymphoma subtypes, and treatment outcomes.
Main Results:
- Median interval from HIV diagnosis to lymphoma diagnosis was 18 months.
- Median CD4 count at lymphoma diagnosis was 218/mm³.
- Among 18 treated patients, 55.5% were alive and lymphoma-free at 18 months median follow-up; 28% expired during treatment.
Conclusions:
- Treatment for HIV-associated lymphoma can lead to favorable outcomes.
- Encouraging treatment for HIV-associated lymphoma is warranted based on positive remission rates.
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