Related Experiment Video
Updated: May 8, 2026

08:30
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
Published on: March 12, 2016
Depression, anxiety, and disturbed sleep in glaucoma
The Journal of Neuropsychiatry and Clinical Neurosciences
|September 13, 2013
Summary
Glaucoma patients with severe vision loss are more likely to experience depression, anxiety, and sleep problems. Early screening and treatment for these conditions are crucial for managing glaucoma.
Area of Science:
- Ophthalmology
- Psychiatry
- Sleep Medicine
Background:
- Glaucoma is often associated with circadian misalignment, sleep disorders, anxiety, and depression.
- These comorbid conditions in glaucoma patients have been under-researched.
Purpose of the Study:
- To investigate the prevalence of depression, trait anxiety, and sleep disturbances in glaucoma patients.
- To determine if the severity of visual field defects (VFD) predicts these psychological and sleep issues.
Main Methods:
- Comparative analysis of glaucoma patients with progressed VFD versus those with no or minor VFD.
- Logistic-regression analyses to identify predictors of depression, anxiety, and sleep disturbance.
Main Results:
- Patients with progressed glaucoma showed a significantly higher prevalence of depression, trait anxiety, and sleep disturbances.
- Severe VFD were identified as a significant predictor for depression, trait anxiety, and sleep disturbance.
Conclusions:
- There is a significant link between advanced glaucoma and increased rates of depression, anxiety, and sleep disturbances.
- Regular screening for these comorbid conditions is necessary in glaucoma patients.
- Psychochronobiological interventions should be considered for managing glaucoma patients.
Related Concept Videos
Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Photoreceptors and Visual Pathways
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
CNS Depressants: Barbiturates and Benzodiazepines
CNS depressants include drugs from the category of barbiturates and benzodiazepines. They are valuable medications for managing anxiety disorders and insomnia. Barbiturates, once used to induce and maintain sleep, have been replaced mainly by benzodiazepines due to barbiturate's toxicity, tolerance, and overdose risks. They interact with GABAA receptors, leading to sedation at low doses and potentially coma and death at higher doses. Phenobarbital, a long-acting barbiturate, possesses...
Sedatives and Hypnotics Drugs: Miscellaneous Agents
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...

