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Updated: May 7, 2026
Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
Published on: July 31, 2017
Histopathological and immunohistochemical profile in anaplastic gangliogliomas
Alfredo E Romero-Rojas1, Julio A Diaz-Perez, Sandra I Chinchilla-Olaya
1Division of Neuropathology, National Cancer Institute, Bogotá, Colombia.
Background:
The anaplastic ganglioglioma (AG) is the high-grade counterpart of ganglioglioma, a rare mixed tumor composed of neuronal/ganglion and glial cells.
Materials And Methods:
We describe the histopathology and immunohistochemistry in 7 cases of AG and correlate them with the clinical and radiological features.
Results:
Our AG patients correspond to 2.5% of the central nervous system tumor patients evaluated in our institution. The mean age at presentation was 25.7 years, with a male predominance. The most common clinical presentation was generalized tonic-clonic seizures (3/7 cases), in correlation with frequent cortical/subcortical location (6/7 cases). Histopathologically, all our cases showed high-grade features in glial (glial fibrillary acid protein-positive) and neuron-ganglion cells (synaptophysin, PGP-9.5, neurofilament, NSE and CD56-positive), as well as moderate cellularity, frequent mitotic figures and a Ki-67 labeling index >5%. All our patients had poor survival.
Conclusion:
We found that a typical histopathological and immunohistochemical profile is constant and can be useful in early diagnosis of these aggressive neoplasms.
