Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Desmosomes01:05

Desmosomes

The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein complexes comprising desmosomal...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Peptic Ulcer01:27

Peptic Ulcer

Peptic ulcers are erosive lesions of the gastric or duodenal lining, most commonly caused by Helicobacter pylori infection. This Gram-negative, helical bacterium has adapted to survive the stomach’s acidic environment by producing urease, which converts urea into ammonia and carbon dioxide. The ammonia neutralizes gastric acid in the bacterium’s immediate environment, allowing colonization of the gastric mucosa. H. pylori attaches to mucus-secreting epithelial cells, penetrates the mucus...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
Peptic Ulcer Disease I: Introduction01:25

Peptic Ulcer Disease I: Introduction

Peptic ulcer disease (PUD) involves breaks in the gastrointestinal tract's mucosal lining, primarily in the stomach and duodenum, with less frequent occurrences in the lower esophagus or near the pylorus.Ulcers can be acute or chronic. Acute ulcers are short-lived with minimal inflammation and heal quickly after the irritant is removed. Chronic ulcers persist, may recur, and often cause scarring due to ongoing tissue damage. Superficial erosions affect only the mucosal layer and are called...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cognitive impairment is associated with poorer oral health in people with HIV: evidence from a pilot study.

Quintessence international (Berlin, Germany : 1985)·2025
Same author

Multidisciplinary approach to diagnosis and management of lymphadenopathy in a patient with mucous membrane pemphigoid: a case report.

General dentistry·2025
Same author

Oral Cancer: An Update.

Dental clinics of North America·2025
Same author

Tongue Coating: a Clinical Case for Healthcare Provider Education.

Journal of cancer education : the official journal of the American Association for Cancer Education·2025
Same author

Oral complications associated with trigeminal trophic syndrome: A case report.

Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·2024
Same author

Area Deprivation and Disease Severity in Adult Patients With Discoid Lupus Erythematosus.

JAMA dermatology·2024
Same journal

Contemporary Oral and Maxillofacial Trauma: A Dental Perspective.

Dental clinics of North America·2026
Same journal

The Expanding Role of Virtual Surgical Planning in Maxillofacial Trauma Management.

Dental clinics of North America·2026
Same journal

Revision Surgery for Occlusal Correction in Facial Trauma.

Dental clinics of North America·2026
Same journal

Mandibular Condylar Fractures and Occlusal Management.

Dental clinics of North America·2026
Same journal

Occlusion Management in Facial Trauma: A Literature Review.

Dental clinics of North America·2026
Same journal

Dental Implants in Rehabilitation of Patients with Facial Trauma: a Review of Most Current Practices.

Dental clinics of North America·2026
See all related articles

Related Experiment Video

Updated: May 7, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Pemphigus.

Frank A Santoro1, Eric T Stoopler, Victoria P Werth

  • 1Department of Dermatology, Henry Ford Hospital, 3031 West Grand Boulevard, Suite 800, Detroit, MI 48202, USA; Department of Dermatology, Philadelphia VA Medical Center, 3900 Woodland Avenue, Philadelphia, PA 19104, USA.

Dental Clinics of North America
|September 17, 2013
PubMed
Summary
This summary is machine-generated.

Pemphigus vulgaris and paraneoplastic pemphigus are autoimmune blistering diseases affecting the oral mucosa. Treatments like immunosuppressive agents and rituximab show promise, especially for severe or refractory cases.

Keywords:
AcantholysisBlistering disorderOral erosionsParaneoplastic pemphigusPemphigusRituximabStomatitis

More Related Videos

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
05:05

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Published on: June 17, 2025

Related Experiment Videos

Last Updated: May 7, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
05:05

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Published on: June 17, 2025

Area of Science:

  • Dermatology
  • Immunology
  • Oncology

Background:

  • Pemphigus vulgaris and paraneoplastic pemphigus are autoimmune blistering disorders affecting the oral mucosa.
  • These conditions are characterized by antibodies targeting keratinocyte adhesion proteins, leading to acantholysis.
  • Clinical manifestations include oral erosions and cutaneous blisters.

Purpose of the Study:

  • To summarize the understanding of pemphigus vulgaris and paraneoplastic pemphigus.
  • To highlight clinical findings and diagnostic considerations.
  • To review current and emerging treatment strategies.

Main Methods:

  • Review of retrospective uncontrolled studies on immunosuppressive agents for pemphigus vulgaris.
  • Analysis of cohort uncontrolled studies on rituximab for refractory pemphigus.
  • Discussion of ongoing research into early disease treatment.

Main Results:

  • Immunosuppressive agents may reduce mortality in pemphigus vulgaris.
  • Rituximab demonstrates efficacy in treating refractory pemphigus patients.
  • Further investigation is needed for paraneoplastic pemphigus malignancy workup.

Conclusions:

  • Pemphigus subtypes require distinct management approaches.
  • Rituximab is a potential treatment for refractory pemphigus.
  • Early disease treatment and malignancy screening are crucial for patient outcomes.