Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Surface Membrane Barriers01:18

Surface Membrane Barriers

The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors01:24

Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors

Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI)  tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining. Bicarbonate,...
Desmosomes01:05

Desmosomes

The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein complexes comprising desmosomal...
Peptic Ulcer Disease II: Pathophysiology01:28

Peptic Ulcer Disease II: Pathophysiology

Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
Types of Membrane Protrusions01:28

Types of Membrane Protrusions

The protrusion of the cell surface is an initial step for several cellular processes, including cell migration, phagocytosis, and neurite outgrowth. These membrane protrusions are a result of cytoskeletal rearrangement. The most  widely observed cell protrusions include lamellipodia, pseudopodia, filopodia, microvilli, invadopodia, and podosomes. These protrusions can be of two types — static or dynamic.
The microvilli, an example of stable protrusions, are finger-like projections with a...
Tissue Membranes01:27

Tissue Membranes

A tissue membrane is a thin layer of cells that covers the outside of the body, the organs, internal passageways that lead to the exterior of the body, and the lining of the moveable joint cavities. There are two basic types of tissue membranes— connective tissue and epithelial membranes.
Connective Tissue Membranes
The connective tissue membrane is formed solely from connective tissue. These membranes encapsulate organs, such as the kidneys, and line our movable joints. A synovial membrane is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implementation-focused consensus recommendations for oral cavity cancer prevention and early detection in Latin America and the Caribbean: A Delphi study.

Oral oncology·2026
Same author

Health policy for oral cancer screening in Latin America: Evidence from a scoping review of initiatives, implementation and outcomes.

Journal of cancer policy·2026
Same author

Lupus Pernio.

The British journal of dermatology·2026
Same author

Evolving Principles for Oral Squamous Cell Carcinoma Screening Programs.

Cancers·2026
Same author

COVID-19 vaccination and immunoreactant deposition in non-autoimmune oral mucosal pathologies.

Oral surgery, oral medicine, oral pathology and oral radiology·2026
Same author

Local hyperthermia for cutaneous sporotrichosis: A randomized clinical trial.

Journal of the American Academy of Dermatology·2026
Same journal

Contemporary Oral and Maxillofacial Trauma: A Dental Perspective.

Dental clinics of North America·2026
Same journal

The Expanding Role of Virtual Surgical Planning in Maxillofacial Trauma Management.

Dental clinics of North America·2026
Same journal

Revision Surgery for Occlusal Correction in Facial Trauma.

Dental clinics of North America·2026
Same journal

Mandibular Condylar Fractures and Occlusal Management.

Dental clinics of North America·2026
Same journal

Occlusion Management in Facial Trauma: A Literature Review.

Dental clinics of North America·2026
Same journal

Dental Implants in Rehabilitation of Patients with Facial Trauma: a Review of Most Current Practices.

Dental clinics of North America·2026
See all related articles

Related Experiment Video

Updated: May 7, 2026

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
05:05

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Published on: June 17, 2025

Mucous membrane pemphigoid.

Hong-Hui Xu1, Victoria P Werth, Ernesta Parisi

  • 1Department of Dermatology, No.1 Hospital of China Medical University, 155 North Nanjing Street, Shenyang 110001, China; Department of Dermatology, Philadelphia VA Medical Center, 3900 Woodland Avenue, Philadelphia, PA 19104, USA.

Dental Clinics of North America
|September 17, 2013
PubMed
Summary
This summary is machine-generated.

Mucous membrane pemphigoid (MMP) is a chronic autoimmune condition requiring accurate diagnosis through pathology and immunology. While treatments exist, progressive disease may lead to scarring and necessitate surgical intervention for functional improvement.

Keywords:
Cicatricial pemphigoidMucous membraneOcularOralSubepithelial autoimmune disease

More Related Videos

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Related Experiment Videos

Last Updated: May 7, 2026

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
05:05

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Published on: June 17, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Area of Science:

  • Autoimmune blistering diseases
  • Dermatology
  • Immunopathology

Background:

  • Mucous membrane pemphigoid (MMP) is a chronic autoimmune subepithelial blistering disease.
  • Characterized by exacerbations and remissions of clinical manifestations.
  • Diagnosis and management often require a multidisciplinary approach.

Purpose of the Study:

  • To outline diagnostic strategies for mucous membrane pemphigoid.
  • To discuss current therapeutic options for MMP.
  • To highlight the challenges in managing progressive MMP and its complications.

Main Methods:

  • Utilizing pathologic and immunologic techniques for diagnosis.
  • Reviewing the role of multidisciplinary collaboration.
  • Assessing the efficacy of systemic adjuvant immunosuppressive therapy and biologics.

Main Results:

  • Accurate diagnosis relies on integrating clinical, pathologic, and immunologic findings.
  • Systemic immunosuppressive therapy is crucial for managing progressive MMP.
  • Despite advances, scarring remains a significant complication, often requiring surgical management.

Conclusions:

  • Early and accurate diagnosis of MMP is essential for effective management.
  • Multidisciplinary care and appropriate immunosuppressive therapy are key to controlling the disease.
  • Surgical intervention may be necessary to restore function and improve quality of life in cases with significant scarring.