Related Experiment Video
Updated: Aug 1, 2026

14:23
Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
Published on: April 16, 2012
Restricted expression of p55 interleukin 2 receptor (CD25) on normal T cells
A L Jackson1, H Matsumoto, M Janszen
1Becton Dickinson Monoclonal Center, Incorporated, Mountain View, California 94043.
Clinical Immunology and Immunopathology
|January 1, 1990
Abstract:
Using a phycoerythrin-conjugated antibody to the p55 chain of the interleukin 2 receptor, normal blood lymphocytes were found to be on average 30% positive for this marker. Two-thirds of these cells are in the CD4 subset and most are within the CD45RA negative fraction associated with activated or memory T cells.
Related Concept Videos
T Cell Activation and Clonal Selection
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
T Cell Types and Functions
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

