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Development of Immunocompetence

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Avoiding complacency and maintaining progress in routine immunization.

David W Brown1, Rouslan Karimov, Marta Gacic-Dobo

  • 1United Nations Children's Fund (UNICEF), 3 UN Plaza, New York, New York 10017, USA.

International Health
|September 17, 2013
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Many countries, especially low-income ones, are not meeting global immunization targets for diphtheria, tetanus, pertussis vaccine (DTP3). Improved routine immunization coverage is still needed worldwide to combat vaccine-preventable diseases.

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Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

Area of Science:

  • Public Health
  • Epidemiology
  • Global Health

Background:

  • Global Immunization Vision and Strategy (GIVS) set targets for national immunization coverage.
  • Vaccine-preventable diseases remain a significant global health challenge.
  • Childhood immunization efforts have shown extraordinary improvements.

Purpose of the Study:

  • To review estimated coverage of three doses of diphtheria, tetanus, pertussis vaccine (DTP3).
  • To assess progress towards GIVS goals for immunization coverage.
  • To identify opportunities for improving global routine immunization.

Main Methods:

  • Review of estimated DTP3 vaccine coverage data.
  • Analysis of progress towards GIVS coverage goals by country income level.

Main Results:

  • Many countries are projected to miss the 2010/2015 GIVS targets for DTP3 coverage.
  • 42% of low-income countries made insufficient or no progress, versus 8% of high-income countries.
  • Significant disparities exist in immunization coverage progress between income groups.

Conclusions:

  • Current DTP3 coverage trends indicate a failure to meet global immunization goals.
  • Low-income countries face greater challenges in achieving and sustaining immunization coverage.
  • Continued efforts are essential to improve routine immunization and reduce vaccine-preventable disease burden.