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Published on: August 6, 2019
Chemotherapy. A viable periodontal treatment modality?
1University of Medicine and Dentistry of New Jersey, Newark.
Dental Clinics of North America
|January 1, 1990
Summary
Chemotherapy shows potential for preventing and treating periodontal disease by targeting bacterial plaque. However, its effectiveness against subgingival plaque remains limited due to challenges in drug delivery and predicting disease activity.
Area of Science:
- Periodontology
- Microbiology
- Pharmacology
Background:
- Bacterial plaque is a primary factor in periodontal disease.
- Chemotherapeutic agents offer a conceptually valid approach to plaque inhibition.
Purpose of the Study:
- To evaluate the role and limitations of chemotherapeutic agents in periodontal disease treatment.
- To explore the potential of chemotherapy in managing supragingival and subgingival plaque.
Main Methods:
- Review of existing literature on chemotherapy for gingivitis and periodontitis.
- Discussion of drug delivery systems for subgingival plaque control.
- Analysis of challenges in targeting specific microbial floras and predicting disease activity.
Main Results:
- Chemotherapy is effective for gingivitis but its role in periodontitis is inconclusive.
- Systemic administration or controlled delivery systems are needed for subgingival plaque.
- Antibiotic use in refractory periodontitis requires careful consideration of adverse reactions.
Conclusions:
- Controlling both supragingival and subgingival plaque is crucial for periodontal disease treatment.
- Current use of chemotherapy for subgingival plaque is limited and impractical.
- Future advancements in predicting disease activity may enhance the role of chemotherapy in periodontitis management.
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