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Updated: May 7, 2026

Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches
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Increased RP105-Negative B Cells in IgG4-Related Disease.

S Koarada1, S Tashiro, N Nagao

  • 1Division of Rheumatology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan.

The Open Rheumatology Journal
|September 17, 2013
PubMed
Summary
This summary is machine-generated.

Increased RP105-negative B cells may indicate active IgG4-related disease (IgG4-RD). Treatment reduced these cells, suggesting RP105 expression analysis could help monitor disease activity in IgG4-RD patients.

Keywords:
IgG4-related diseaseRP105-negative B cellsplasma cellsplasmablasts.

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Area of Science:

  • Immunology
  • Rheumatology
  • Pathology

Background:

  • Immunoglobulin G4-related disease (IgG4-RD) is a fibroinflammatory condition affecting multiple organs.
  • B cells play a role in the pathogenesis of IgG4-RD, but specific B cell subsets involved are not fully elucidated.
  • RP105 is a B cell surface receptor whose expression patterns in IgG4-RD are largely unknown.

Purpose of the Study:

  • To investigate the prevalence and potential role of RP105-negative B cells in patients with IgG4-related disease.
  • To determine if the percentage of RP105-negative B cells correlates with disease activity or treatment response in IgG4-RD.

Main Methods:

  • Flow cytometry analysis was used to quantify RP105-negative B cells in the peripheral blood of four IgG4-RD patients.
  • Clinical data, including affected lesions and treatment responses, were collected for each patient.
  • Changes in RP105-negative B cell percentages before and after treatment were assessed.

Main Results:

  • All four IgG4-related disease patients presented with elevated percentages of RP105-negative B cells.
  • In Case 1, treatment with oral prednisolone led to a significant decrease in RP105-negative B cells (from 18.8% to 3.2%) concurrent with lesion improvement.
  • The other three patients also showed decreased RP105-negative B cell counts following treatment, suggesting a link between these cells and disease activity.

Conclusions:

  • Elevated levels of RP105-negative B cells in peripheral blood are potentially associated with active IgG4-related disease.
  • Monitoring RP105 expression on B cells may serve as a useful biomarker for evaluating IgG4-RD disease activity and treatment efficacy.