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Related Experiment Video

Updated: May 7, 2026

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Published on: January 12, 2017

Is pulp regeneration necessary for root maturation?

Ali Nosrat¹, Kevin L Li, Kunwar Vir

¹Department of Endodontics, Prosthodontics and Operative Dentistry, School of Dentistry, University of Maryland, Baltimore, Maryland.

Journal of Endodontics

|September 18, 2013

Summary

This summary is machine-generated.

Regenerative endodontic treatment in immature teeth with necrotic pulps achieved root apex formation and healed lesions but did not regenerate pulp tissue. Augmentin may be suitable for root canal disinfection.

Keywords:

Augmentin dental trauma mineral trioxide aggregate pulp regeneration regenerative endodontic treatment root development

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Last Updated: May 7, 2026

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Area of Science:

Regenerative Endodontics
Endodontic Microbiology
Dental Traumatology

Background:

Histological evidence of true pulp-dentin complex regeneration in immature necrotic teeth remains elusive.
The clinical necessity of complete tissue regeneration for successful outcomes in regenerative endodontics is unclear.

Observation:

A case report details the treatment of an immature incisor with pulp necrosis and apical abscess following trauma.
A regenerative endodontic protocol utilized an Augmentin paste for intracanal disinfection over five weeks.
Clinical and radiographic follow-ups assessed healing and tissue regeneration.

Findings:

Complete osseous healing of the periapical lesion and root apex formation were observed without root lengthening.
The treated tooth remained functional and asymptomatic, but the crown discolored.
No regenerated tissue was found within the root canal space upon re-entry.

Implications:

Augmentin shows potential as an intracanal disinfectant in regenerative endodontic procedures.
Current regenerative endodontic protocols are not consistently predictable for achieving pulp-dentin regeneration.
Root apex formation is achievable even in the absence of pulp regeneration.