Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Antigen Presenting Cells01:22

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

uPA-mediated remodeling of CCL21 gradients regulates lymphatic migration of dendritic cells.

The Journal of cell biology·2026
Same author

Bioengineered Lymphatic Vessels in Synthetic Matrices to Study Breast Cancer Cell Functions.

Advanced healthcare materials·2026
Same author

Transcriptomics- and 3D imaging-based characterization of the lymphatic vasculature in human skin.

The Journal of experimental medicine·2025
Same author

Lymph nodes fuel KLF2-dependent effector CD8<sup>+</sup> T cell differentiation during chronic infection and checkpoint blockade.

Nature immunology·2025
Same author

GM-CSF derived from alveolar type 2 cells promotes CD301b<sup>+</sup> cDC2 generation and allergic airway inflammation.

Science immunology·2025
Same author

Combinatorial treatment with upadacitinib abrogates systemic toxicity of a tumor-targeted IL-2 fusion protein.

Journal for immunotherapy of cancer·2025
Same journal

Prevalence and Predictors of Cancer-Related Fatigue in Breast Cancer-Related Lymphedema Patients: A Cross-Sectional Study.

Lymphatic research and biology·2026
Same journal

The Effect of a Series of Lower Limb Pressotherapy Treatments on the Range of Motion of the Lower Limb Joints, Lower Limb Circumferences, and Body Composition in Young, Healthy Women.

Lymphatic research and biology·2026
Same journal

<sup>23</sup>Na-MRI Measures Tissue Sodium in Human Leg Lymphedema.

Lymphatic research and biology·2026
Same journal

Inflammatory Markers in Lipedema: A Comparative Analysis of Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Mean Platelet Volume.

Lymphatic research and biology·2026
Same journal

Neuropathic Pain Features in Lipedema Compared to Lymphedema: An Exploratory Cross-Sectional Study.

Lymphatic research and biology·2026
Same journal

Lipedema: Exploring Relationship Between Physical and Psychological Symptoms in Affected Patients-A Mixed-Methods Study.

Lymphatic research and biology·2026
See all related articles

Related Experiment Video

Updated: May 7, 2026

An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics
09:25

An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics

Published on: December 24, 2015

Dendritic cell interactions with lymphatic endothelium.

Erica Russo1, Maximilian Nitschké, Cornelia Halin

  • 1Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology , ETH Zurich, Switzerland .

Lymphatic Research and Biology
|September 19, 2013
PubMed
Summary
This summary is machine-generated.

Dendritic cells (DCs) migrate through lymphatic vessels to lymph nodes, initiating immune responses. Recent imaging tools reveal cellular interactions between DCs and lymphatic endothelium, advancing our understanding of immune cell trafficking.

More Related Videos

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
07:35

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

Published on: December 24, 2016

Isolation of Murine Lymph Node Stromal Cells
05:47

Isolation of Murine Lymph Node Stromal Cells

Published on: August 19, 2014

Related Experiment Videos

Last Updated: May 7, 2026

An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics
09:25

An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics

Published on: December 24, 2015

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
07:35

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

Published on: December 24, 2016

Isolation of Murine Lymph Node Stromal Cells
05:47

Isolation of Murine Lymph Node Stromal Cells

Published on: August 19, 2014

Area of Science:

  • Immunology
  • Cell Biology
  • Vascular Biology

Background:

  • Afferent lymphatic vessels are crucial for immune surveillance, transporting antigens and leukocytes to lymph nodes.
  • Dendritic cells (DCs) are key immune cells that capture antigens in peripheral tissues and migrate via lymphatics to lymph nodes.
  • DCs play a vital role in initiating adaptive immunity, vaccination responses, and maintaining immune tolerance.

Purpose of the Study:

  • To review current methods for visualizing dendritic cells and lymphatic vessels in tissues.
  • To summarize the current understanding of dendritic cell migration into, within, and towards lymphatic vessels.
  • To highlight the cellular interactions between dendritic cells and lymphatic endothelial cells during migration.

Main Methods:

  • Review of existing literature and imaging techniques.
  • Focus on advancements in visualization tools, including time-lapse microscopy.
  • Analysis of cellular interactions at the interface of dendritic cells and lymphatic endothelium.

Main Results:

  • New imaging technologies have significantly improved the visualization of lymphatic vessels and DC migration.
  • Detailed insights into the cellular mechanisms governing DC entry and transit within lymphatic vessels are emerging.
  • Specific cellular interactions between DCs and lymphatic endothelial cells are critical for efficient migration.

Conclusions:

  • Understanding DC-lymphatic vessel interactions is crucial for deciphering immune response initiation.
  • Advanced imaging techniques are key to unraveling the complexities of immune cell trafficking.
  • Further research into these cellular interactions will impact fields from vaccinology to immunotherapy.