(-)-Norfluoro-curarine ethanol monosolvate

Area of Science:

• Natural Product Chemistry
• Structural Chemistry
• Crystallography

Background:

• Vinca erecta is a plant source of various bioactive alkaloids.
• Indole alkaloids represent a significant class of natural products with diverse pharmacological properties.
• Understanding the structural characteristics of these compounds is crucial for further research.

Purpose of the Study:

• To elucidate the crystal structure of an ethanol solvate of norfulorocurarine.
• To determine the molecular conformation and intermolecular interactions within the crystal lattice.
• To characterize the hydrogen bonding network in the solid state.

Main Methods:

• Single-crystal X-ray diffraction was employed to determine the crystal structure.
• The crystal structure analysis involved identifying atomic positions and bond lengths/angles.
• Conformational analysis of the piperidine and pyrrolidine rings was performed.

Main Results:

• The compound was identified as an ethanol solvate of norfulorocurarine (C19H20N2O·C2H5OH).
• The piperidine ring adopted a boat conformation, and the pyrrolidine ring adopted an envelope conformation.
• An intramolecular N-H⋯O hydrogen bond formed an S6 ring motif, and intermolecular N-H⋯O and O-H⋯N bonds linked molecules into chains.

Conclusions:

• The crystal structure of norfulorocurarine ethanol solvate was successfully determined.
• The study provides detailed insights into the conformational preferences and hydrogen bonding of this indole alkaloid.
• The findings contribute to the understanding of the solid-state behavior of natural products.