Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The hyaluronan receptor CD44 drives COVID-19 severity through its regulation of neutrophil migration.

PLoS pathogens·2026
Same author

Local Immunometabolic Intervention With Alanyl-Glutamine Resolves Peritoneal Dialysis-Induced Immune Cell Dysfunction.

Kidney international reports·2026
Same author

IL-4 treatment induces apoptosis of blood monocytes and proliferation of recruited injury-associated macrophages to resolve liver injury.

Cell reports·2026
Same author

Immunobiology of the serous cavities.

Science immunology·2026
Same author

CD154 Restricts Helminth-Induced Macrophage Polarisation and Proliferation While Promoting Tissue Residence.

Parasite immunology·2025
Same author

The hyaluronan receptor CD44 drives COVID-19 severity through its regulation of neutrophil migration.

bioRxiv : the preprint server for biology·2025
Same journal

Pregnancy-induced tissue-resident memory-like T cells contribute to tumor control in breast cancer.

Nature immunology·2026
Same journal

Mechanosensing by T cells promotes a tissue-resident memory transcriptional program.

Nature immunology·2026
Same journal

Editorial Expression of Concern: Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells.

Nature immunology·2026
Same journal

Inflammatory immune modulators of AML lung infiltration and respiratory failure.

Nature immunology·2026
Same journal

The neuroimmune system and cognition.

Nature immunology·2026
Same journal

Critical connections.

Nature immunology·2026
See all related articles

Related Experiment Video

Updated: May 7, 2026

Interrogating Cell-Cell Interactions in the Salivary Gland via Ex Vivo Live Cell Imaging
05:40

Interrogating Cell-Cell Interactions in the Salivary Gland via Ex Vivo Live Cell Imaging

Published on: November 17, 2023

Tissue-resident macrophages.

Luke C Davies1, Stephen J Jenkins, Judith E Allen

  • 1Cardiff Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.

Nature Immunology
|September 20, 2013
PubMed
Summary
This summary is machine-generated.

Tissue-resident macrophages exhibit diverse functions and origins, influenced by their specific tissue environments. Understanding these niche-specific factors is key to restoring tissue health and function.

More Related Videos

Isolation of Murine Peritoneal Macrophages to Carry Out Gene Expression Analysis Upon Toll-like Receptors Stimulation
08:21

Isolation of Murine Peritoneal Macrophages to Carry Out Gene Expression Analysis Upon Toll-like Receptors Stimulation

Published on: April 29, 2015

Isolation and Culture of Resident Cardiac Macrophages from the Murine Sinoatrial and Atrioventricular Node
08:43

Isolation and Culture of Resident Cardiac Macrophages from the Murine Sinoatrial and Atrioventricular Node

Published on: May 7, 2021

Related Experiment Videos

Last Updated: May 7, 2026

Interrogating Cell-Cell Interactions in the Salivary Gland via Ex Vivo Live Cell Imaging
05:40

Interrogating Cell-Cell Interactions in the Salivary Gland via Ex Vivo Live Cell Imaging

Published on: November 17, 2023

Isolation of Murine Peritoneal Macrophages to Carry Out Gene Expression Analysis Upon Toll-like Receptors Stimulation
08:21

Isolation of Murine Peritoneal Macrophages to Carry Out Gene Expression Analysis Upon Toll-like Receptors Stimulation

Published on: April 29, 2015

Isolation and Culture of Resident Cardiac Macrophages from the Murine Sinoatrial and Atrioventricular Node
08:43

Isolation and Culture of Resident Cardiac Macrophages from the Murine Sinoatrial and Atrioventricular Node

Published on: May 7, 2021

Area of Science:

  • Immunology
  • Cell Biology
  • Tissue Homeostasis

Background:

  • Tissue-resident macrophages are crucial immune cells with specialized functions.
  • Their origins are diverse, stemming from both hematopoietic and embryonic sources.
  • Macrophage heterogeneity is critical for tissue-specific roles.

Purpose of the Study:

  • To explore the heterogeneity of tissue-resident macrophages.
  • To understand the influence of tissue niches on macrophage phenotype.
  • To identify strategies for restoring tissue homeostasis.

Main Methods:

  • Review of recent studies on macrophage origins and heterogeneity.
  • Analysis of tissue niche-specific factors influencing macrophage phenotype.
  • Discussion of mechanisms driving macrophage diversity in vivo.

Main Results:

  • Tissue macrophages display significant heterogeneity in origin and function.
  • Tissue microenvironments dictate macrophage phenotype and specialization.
  • Embryo-derived and hematopoietic origins contribute to macrophage diversity.

Conclusions:

  • Tissue niche factors are critical determinants of macrophage phenotype.
  • Understanding macrophage heterogeneity is essential for developing therapeutic strategies.
  • Restoring tissue homeostasis relies on addressing macrophage diversity.