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Ioxilan, a third generation low osmolality nonionic contrast medium. Systemic and renal hemodynamic effects.
R W Katzberg1, L A Donahue, T W Morris
1Department of Radiology, University of Rochester Medical Center, New York.
Investigative Radiology
|January 1, 1990
Summary
Ioxilan, a new nonionic contrast media (CM), demonstrated biological equivalence to Iohexol in canine studies. This low osmolality CM offers good tolerance and effective imaging, presenting a promising alternative for radiologists.
Area of Science:
- Radiology
- Pharmacology
- Medical Imaging
Background:
- Radiologists face a choice between high-cost, low-toxicity nonionic contrast media (CM) and lower-cost ionic CM.
- Ioxilan is a novel, third-generation nonionic CM derived from an ionic CM, designed for low osmolality (570 mOsm at 300 mgI/ml).
Purpose of the Study:
- To evaluate the effects of Ioxilan, a low osmolality nonionic CM, on canine systemic and renal hemodynamics compared to Iohexol.
- To assess the safety and efficacy of Ioxilan for radiographic imaging.
Main Methods:
- Intravenous (IV) bolus injections of Iohexol and Ioxilan (350 mgI/ml at 2 ml/kg) were administered to canines.
- Systemic and renal hemodynamics were monitored.
- Nephrograms and pyelograms were obtained and compared.
Main Results:
- Both Iohexol and Ioxilan produced satisfactory nephrograms and pyelograms with no significant differences in image quality.
- The effects of both CM on systemic and renal hemodynamics were minimal and statistically equivalent.
- Ioxilan demonstrated good biological tolerance.
Conclusions:
- Ioxilan and Iohexol are biologically equivalent in terms of acute systemic and renal responses and radiographic image quality.
- The molecular design of Ioxilan achieves very low osmolality while ensuring good biological tolerance.
- Ioxilan represents an economically promising, low osmolality nonionic CM option for radiologists.