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Simulating the Mechanics of Lens Accommodation via a Manual Lens Stretcher
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Static and dynamic crystalline lens accommodation evaluated using quantitative 3-D OCT.

Enrique Gambra1, Sergio Ortiz, Pablo Perez-Merino

  • 1Instituto de Óptica "Daza de Valdés", Consejo Superior de Investigaciones Científicas, C/Serrano 121, 28006 Madrid, Spain.

Biomedical Optics Express
|September 20, 2013
PubMed
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High-speed optical coherence tomography (OCT) revealed how the human crystalline lens changes shape during accommodation. These changes, particularly in lens curvature, influence the eye's optical power and accommodative response fluctuations.

Area of Science:

  • Ophthalmology
  • Biomedical Optics
  • Vision Science

Background:

  • Understanding the human crystalline lens's in vivo behavior is crucial for addressing refractive errors and developing advanced optical models.
  • Previous studies often relied on ex vivo or lower-resolution imaging, limiting dynamic analysis of lens changes during accommodation.

Purpose of the Study:

  • To three-dimensionally characterize the human crystalline lens in vivo across a range of accommodative demands (0-6 D).
  • To quantify dynamic changes in lens geometry and their impact on ocular power during accommodation.
  • To identify the primary drivers of accommodative response fluctuations.

Main Methods:

  • Utilized custom high-resolution, high-speed anterior segment spectral domain Optical Coherence Tomography (OCT) with automated quantification and distortion correction.
Keywords:
(110.4500) Optical coherence tomography(110.6880) Three-dimensional image acquisition(120.4640) Optical instruments(120.6650) Surface measurements, figure(330.7322) Visual optics, accommodation(330.7327) Visual optics, ophthalmic instrumentation

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  • Acquired dynamic 2-D OCT images (14 Hz) during steady fixation for 5-second intervals at 1 D accommodative steps.
  • Analyzed changes in lens radii of curvature, anterior chamber depth, and lens thickness.

    • Main Results:

    • Anterior and posterior lens radii of curvature decreased with accommodation at 0.73 mm/D and 0.20 mm/D, respectively.
    • Ocular optical power increased by an estimated 0.62 D per diopter of accommodative demand.
    • Fluctuations in accommodative response increased from 0.07 D to 0.47 D (0.044 D per D) with increasing demand, driven by dynamic changes in lens surfaces, especially the posterior surface.

    Conclusions:

    • In vivo OCT provides detailed 3-D characterization of crystalline lens dynamics during accommodation.
    • Dynamic changes in lens curvature significantly contribute to the eye's optical power modulation and accommodative response variability.
    • The posterior lens surface plays a critical role in driving fluctuations in accommodation.