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Idiopathic osteoporosis in men.
Luigi Gennari1, John P Bilezikian
1Department of Medicine, Surgery and Neurosciences, University of Siena, Viale Bracci, 53100, Siena, Italy, gennari@unisi.it.
Current Osteoporosis Reports
|September 21, 2013
Summary
Osteoporosis in men is increasingly recognized, with new insights into bone health, pathophysiology, and treatment. This review focuses on idiopathic osteoporosis, addressing knowledge gaps in its cause and management.
Area of Science:
- Bone biology and osteoporosis research.
- Men's health and aging.
Background:
- Osteoporosis in men is a growing concern, receiving increased research attention.
- Recent population studies have advanced understanding of bone metabolism in males.
- Fracture risk rises after age 65, with secondary causes in 50% of cases.
Purpose of the Study:
- To summarize recent advancements in bone strength acquisition and maintenance in men.
- To provide new insights into the pathogenesis, diagnosis, and treatment of idiopathic osteoporosis.
- To address knowledge gaps regarding the etiology and clinical management of idiopathic osteoporosis.
Main Methods:
- Review of recent large-scale population studies.
- Analysis of morphologic basis of bone growth, maintenance, and loss in men.
- Synthesis of current knowledge on pathophysiology and treatment.
Main Results:
- Enhanced understanding of bone dynamics in men.
- Identification of secondary etiologies contributing to fractures in older men.
- Highlighting the challenges and gaps in managing idiopathic osteoporosis in younger/middle-aged men.
Conclusions:
- Significant progress has been made in understanding male osteoporosis.
- Idiopathic osteoporosis in men remains a complex area with unmet needs in etiology and management.
- Further research is crucial for improving diagnosis and treatment strategies.
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