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Updated: May 7, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
Catheter ablation of atrial fibrillation in heart failure
Senthil Kirubakaran1, Mark D O'Neill
1Cardiothoracic Department, Guy's and St Thomas' NHS Trust, Westminster Bridge Road, London SE1 7EH, UK.
Insights
Atrial fibrillation with heart failure predicts mortality. Catheter ablation effectively restores sinus rhythm, improving heart function and quality of life in these patients.
Area of Science:
- Cardiology
- Electrophysiology
Background:
- Atrial fibrillation in heart failure patients independently predicts mortality.
- It is linked to increased hospitalizations and worsening functional class.
- Previous trials showed no benefit in rhythm restoration, but survival improved in those maintaining sinus rhythm.
Purpose of the Study:
- To examine the efficacy of catheter ablation for atrial fibrillation in heart failure patients.
- To assess the impact of maintaining sinus rhythm on patient outcomes.
Main Methods:
- Studies were conducted to evaluate catheter ablation efficacy.
- Outcomes measured included sinus rhythm maintenance, left ventricular ejection fraction, quality of life, and functional class.
Main Results:
- Catheter ablation demonstrated efficacy rates from 50% to 92% in maintaining sinus rhythm.
- Patients undergoing ablation showed improvements in left ventricular ejection fraction.
- Quality of life and New York Heart Association functional class also improved.
Conclusions:
- Catheter ablation is an effective strategy for managing atrial fibrillation in heart failure.
- Restoring and maintaining sinus rhythm improves cardiac function and patient well-being.
Abstract:
Atrial fibrillation in the presence of heart failure is an independent predictor of mortality and is associated with increased hospitalizations and worsening New York Heart Association functional class. Despite these associations, large-scale trials have not shown a benefit in rhythm restoration. However, further analysis of these trials showed that patients who remained in sinus rhythm did have improved survival rates. Studies to examine the efficacy of catheter ablation of atrial fibrillation were therefore conducted and reported efficacy rates ranging from 50% to 92% at maintaining sinus rhythm with associated improvements in left ventricular ejection fraction, quality of life, and New York Heart Association functional class.
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