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The tumor suppressor function of STAT1 in breast cancer

Antonis E Koromilas1, Veronika Sexl

  • 1Lady Davis Institute for Medical Research and Segal Cancer Centre; Sir Mortimer B. Davis-Jewish General Hospital; Montreal, QC Canada ; Department of Oncology; Faculty of Medicine; McGill University; Montreal, QC Canada.

JAK-STAT
|September 24, 2013
PubMed

Insights

Signal transducer and activator of transcription 1 (STAT1) suppresses breast cancer through immune surveillance and direct tumor cell effects. STAT1 deficiency promotes mammary gland tumorigenesis, impacting diverse human breast cancer subtypes.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • The immune-regulatory functions of Signal transducer and activator of transcription 1 (STAT1) in anti-tumor immunity are established.
  • Cell-autonomous roles of STAT1 in tumor formation remain less understood.

Purpose of the Study:

  • To review the anti-tumor functions of STAT1 in breast cancer, encompassing both immune and cell-specific mechanisms.
  • To highlight the prognostic significance and therapeutic implications of STAT1 in breast cancer.

Main Methods:

  • Review of murine mammary gland cancer models investigating STAT1 deficiency.
  • Characterization of STAT1 signaling in human breast tumor cells.

Main Results:

  • STAT1 deficiency in mice promotes ErbB2/Neu-mediated mammary tumorigenesis.
  • STAT1 loss contributes to spontaneous ERα-positive and ERα-negative tumors resembling human breast cancer.
  • STAT1 expression/phosphorylation shows prognostic value in specific breast cancer subtypes.

Conclusions:

  • STAT1 exerts tumor-suppressive effects via immune surveillance and intrinsic tumor cell functions.
  • STAT1 plays a critical role in diverse breast cancer models and human disease.
  • STAT1 modulation may influence therapeutic responses and drug resistance in breast cancer.
Keywords:
ErbB2/NeuSTAT1breast cancerestrogen receptor αprotein phosphorylationtransgenic mice

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