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Updated: May 7, 2026

Folding and Characterization of a Bio-responsive Robot from DNA Origami
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Repeat protein engineering: creating functional nanostructures/biomaterials from modular building blocks.

Ewan R G Main1, Jonathan J Phillips, Charlotte Millership

  • 1*School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, U.K.

Biochemical Society Transactions
|September 25, 2013
PubMed
Summary

Engineered repeat proteins are versatile building blocks for creating smart nanostructures through self-assembly. These programmable proteins can form diverse morphologies and stimuli-responsive materials for biotechnology applications.

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Area of Science:

  • Biotechnology
  • Materials Science
  • Protein Engineering

Background:

  • Molecular self-assembly is crucial for developing smart nanostructures in biotechnology.
  • Repeat proteins offer a simple sequence-structure-function relationship and modularity.
  • They serve as scaffolds for protein-protein interactions and have been successfully engineered.

Purpose of the Study:

  • To review recent advances in using engineered repeat proteins for self-assembly.
  • To highlight their potential in creating novel materials, nanostructures, and biosensors.
  • To demonstrate their utility as programmable building blocks.

Main Methods:

  • Review of literature on engineered repeat proteins.
  • Analysis of self-assembly properties and applications.

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Last Updated: May 7, 2026

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

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Published on: December 3, 2015

Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
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Published on: November 21, 2013

  • Discussion of design and engineering strategies.

    • Main Results:

    • Engineered repeat proteins act as programmable monomeric building blocks.
    • They can be triggered to self-assemble into various morphologies.
    • These proteins can be engineered into stimuli-responsive biofunctional materials.

    Conclusions:

    • Repeat proteins are ideal for bottom-up fabrication of advanced nanostructures.
    • Their programmability enables the creation of diverse and responsive biomaterials.
    • Significant potential exists for applications in biotechnology and biosensing.