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MicroRNA-650 expression in glioma is associated with prognosis of patients

Boqian Sun1, Bo Pu, Dake Chu

  • 1Medical Department of Neurology, Affiliated Hospital of Beihua University, Jilin, 132011, People's Republic of China, sunboqian@live.cn.

Journal of Neuro-Oncology
|September 25, 2013
PubMed

Insights

MicroRNA-650 (miR-650) is elevated in glioma and indicates a worse prognosis for patients. This microRNA may serve as a valuable prognostic marker for glioma management.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are non-coding RNAs regulating gene expression.
  • Aberrant miRNA expression is linked to various human malignancies.
  • The prognostic role of miR-650 in glioma remains uninvestigated.

Purpose of the Study:

  • To investigate the expression of miR-650 in human glioma.
  • To evaluate the association between miR-650 expression and glioma patient prognosis.

Main Methods:

  • Quantitative real-time PCR to measure miR-650 expression in 168 glioma specimens and 21 normal brain tissues.
  • Kaplan-Meier analysis and Cox's proportional hazards model to assess prognostic value.

Main Results:

  • miR-650 expression was significantly higher in glioma tissues compared to normal controls (P < 0.001).
  • Elevated miR-650 correlated with higher World Health Organization grade and lower Karnofsky performance score (KPS) (P < 0.001).
  • High miR-650 expression was associated with significantly poorer patient prognosis.

Conclusions:

  • miR-650 is upregulated in glioma and serves as a significant independent prognostic indicator.
  • miR-650 expression levels can predict patient outcomes in human glioma.
  • This finding may inform novel therapeutic strategies for glioma treatment.

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