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Related Experiment Video

Updated: May 7, 2026

Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine

Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine

Published on: January 30, 2020

Synchronized defibrillation for ventricular fibrillation.

Karen M Darragh¹, Ganesh Manoharan, Cesar Navarro

¹Belfast Health and Social Care Trust, Belfast, UK.

European Heart Journal. Acute Cardiovascular Care

|September 25, 2013

Summary

Synchronized transthoracic defibrillation, timed to the ventricular fibrillation (VF) wave

Keywords:

Electric defibrillation electrocardiogram external defibrillators impedance swine ventricular fibrillation

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Last Updated: May 7, 2026

Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine

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Published on: January 30, 2020

A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique

A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique

Published on: April 26, 2015

Area of Science:

Cardiology
Medical Devices
Electrophysiology

Background:

Optimizing defibrillation success is crucial for improving patient outcomes and reducing adverse effects.
Prior research indicated potential benefits of synchronizing intracardiac shocks to the ventricular fibrillation (VF) wave's upslope.

Purpose of the Study:

To evaluate the efficacy of a novel external biphasic defibrillator in achieving transthoracic defibrillation success.
To determine if shocks synchronized to the surface electrocardiogram (ECG) upslope improve defibrillation outcomes compared to non-synchronized shocks.

Main Methods:

A prospective, randomized study was conducted on 10 pigs.
Ventricular fibrillation was induced, and biphasic shocks were delivered using a novel defibrillator in synchronized or non-synchronized modes.
Various energy levels (50-100J) were tested, with VF amplitude, impedance, and shock success recorded.

Main Results:

Synchronized shocks were delivered on the VF wave's upslope in 99% of attempts.
No significant difference in shock success was observed between synchronized and non-synchronized shock delivery (p=0.695).
VF amplitude and transthoracic impedance did not correlate with shock success.

Conclusions:

The novel defibrillator effectively delivered shocks synchronized to the VF wave's upslope.
Synchronization to the VF wave's upslope did not improve transthoracic defibrillation success in this study.
Further research may be needed to explore other synchronization strategies or defibrillation parameters.