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[An update on celiac disease]
1Service de gastroentérologie et d'hépatologie, CHUV, 1011 Lausanne. sebastien.godat@chuv.ch
Revue Medicale Suisse
|September 27, 2013
Summary
Celiac disease, affecting both children and adults, presents with diverse symptoms, often outside the gut. Diagnosis relies on serology, genetics, and endoscopy, with a gluten-free diet as primary treatment.
Area of Science:
- Gastroenterology
- Immunology
- Pediatrics
Context:
- Celiac disease is increasingly recognized in adults, extending beyond its traditional pediatric focus.
- Clinical presentations vary widely, including atypical and extraintestinal manifestations.
- Diagnostic approaches involve serologic and genetic testing, complemented by upper gastrointestinal endoscopy.
Purpose:
- To provide a comprehensive overview of celiac disease diagnosis and management.
- To highlight the evolving understanding of celiac disease in different age groups.
- To discuss current and future treatment strategies.
Summary:
- Celiac disease diagnosis utilizes serologic markers, genetic predisposition, and endoscopic biopsy, particularly for atypical cases.
- While a gluten-free diet is the standard treatment, compliance challenges necessitate exploring alternative therapeutic options.
- Potential complications, though infrequent, can be serious, underscoring the importance of timely diagnosis and management.
Impact:
- Enhances understanding of celiac disease's broad clinical spectrum.
- Informs diagnostic strategies for both typical and atypical presentations.
- Guides future research into alternative treatments for improved patient compliance and outcomes.
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