Failure of conflict to modulate central executive network activity associated with delusions in schizophrenia
William J Speechley1, Todd S Woodward, Elton T Ngan
1Department of Psychiatry, Schizophrenia Cognition Imaging Laboratory, University of British Columbia , Vancouver, BC , Canada.
Abstract:
Dual-stream modulation failure (DSMF) proposes that dysfunctional regulation of logical and intuitive decision-making processes by conflict and emotional salience may be the underlying cognitive mechanism for the formation and maintenance of delusions in schizophrenia. The present study utilizes a combination of emotionally salient and neutral stimuli in conflict and non-conflict conditions in a sentence verification task to test specific hypotheses predicted by the model. Twenty-one patients with schizophrenia and 21 controls completed a sentence verification task with fMRI acquisition. The results are consistent with the predictions based on the conflict modulation component of the model, but do not support the emotional modulation component of the model.
More Related Videos
09:26Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
Published on: February 6, 2019
13:20Online Repetitive Transcranial Magnetic Stimulation of Dorsomedial and Dorsolateral Prefrontal Cortex in Cognition Decision Making, and Cognitive Dissonance
Published on: December 5, 2025
Related Concept Videos
Negative and Cognitive Symptoms of Schizophrenia
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Psychological and Sociocultural Causes of Schizophrenia
Positive Symptoms Schizophrenia: Hallucinations and Delusions
Hallucinations
Hallucinations in...
Positive Symptoms of Schizophrenia: Hallucinations and Delusions
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes loosely...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Biological Causes of Schizophrenia
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
