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MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

MicroRNAs

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Related Experiment Video

Updated: May 7, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

[MicroRNAs and cancer].

Mohamed Guled¹, Sakari Knuutila

¹Helsingin yliopisto, Haartman-Instituutti, patologian osasto.

Duodecim; Laaketieteellinen Aikakauskirja

|September 28, 2013

Summary

MicroRNAs (miRNAs) regulate gene expression and are linked to cancer. Researchers are exploring miRNA-based therapies for cancer treatment.

Area of Science:

Molecular Biology
Genetics
Biochemistry

Context:

MicroRNAs (miRNAs) are key regulators of posttranscriptional gene expression.
Their association with cancer has driven extensive research over the past decade.
Advanced genome-wide detection methods enable miRNA profiling across biological systems.

Purpose:

To investigate the role of miRNAs in physiological and pathological processes.
To explore the diagnostic, prognostic, and predictive potential of miRNAs in cancer.
To evaluate miRNA-based therapeutic strategies for cancer treatment.

Summary:

MiRNAs are noncoding RNAs involved in gene expression regulation.
Their significant role in cancer pathology, including tumor development and therapy response, is well-established.

More Related Videos

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR (qPCR)

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR (qPCR)

Published on: May 16, 2012

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier (MSC) for Lung Cancer Screening

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier (MSC) for Lung Cancer Screening

Published on: October 26, 2017

Related Experiment Videos

Last Updated: May 7, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR (qPCR)

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR (qPCR)

Published on: May 16, 2012

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier (MSC) for Lung Cancer Screening

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier (MSC) for Lung Cancer Screening

Published on: October 26, 2017

MiRNAs show promise as biomarkers for cancer diagnosis and prognosis.

Impact:

MiRNA research is crucial for understanding cancer biology.
MiRNAs offer potential as novel biomarkers for personalized cancer medicine.
MiRNA-based anti-cancer therapies are emerging as a future treatment modality.