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Fluorescent and radiolabeled triphenylphosphonium probes for imaging mitochondria

Hushan Yuan1, Hoonsung Cho, Howard H Chen

  • 1Center for Advanced Medical Imaging Sciences, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA. ljosephson@mgh.harvard.edu.

Chemical Communications (Cambridge, England)
|September 28, 2013
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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...