Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Randomized Experiments01:13

Randomized Experiments

The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
Blinding01:11

Blinding

Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Study Designs in Epidemiology01:20

Study Designs in Epidemiology

Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and case-control studies.
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs01:15

Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs

Bioequivalence experimental study designs play a pivotal role in testing the effectiveness of various treatments. Key among these are the repeated measures, cross-over, carry-over, and Latin square designs. In the repeated measures design, each subject receives all treatments, allowing for temporal comparisons. This type of design is useful in reducing variability but requires careful planning to avoid bias.The cross-over design, an economical method, involves sequential administration of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lung Cancer Risk in US Adults with COPD: A Systematic Review and Meta-Analysis.

International journal of chronic obstructive pulmonary disease·2025
Same author

The value of simulation testing for the evaluation of ambient digital scribes: a case report.

Journal of the American Medical Informatics Association : JAMIA·2025
Same author

Accuracy and Safety of AI-Enabled Scribe Technology: Instrument Validation Study.

Journal of medical Internet research·2025
Same author

Accuracy of Noninvasive Blood Pressure Monitoring in Critically Ill Adults.

Journal of intensive care medicine·2024
Same author

Thrombotic and Clinical Outcomes in Patients with Hematologic Malignancy and COVID-19.

Clinical lymphoma, myeloma & leukemia·2022
Same author

Expectant Management of Severe COVID-19 Pneumonia in Late Preterm Pregnancy and Subsequent Cholecystitis: Lessons Learned.

AJP reports·2021

Related Experiment Video

Updated: May 7, 2026

E-Patient Counseling Trial (E-PACO): Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial (E-PACO): Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

Implementation of an online pragmatic randomized controlled trial: a methodological case study.

Nathan K Cobb1, Josée Poirier

  • 1Division of Pulmonary & Critical Care, Department of Medicine, Georgetown University Medical Center, Washington, DC USA ; MeYou Health, LLC, Boston, MA USA.

Translational Behavioral Medicine
|September 28, 2013
PubMed
Summary

Conducting rigorous online trials for eHealth interventions is feasible and efficient. This pragmatic randomized controlled trial demonstrates timely recruitment and data collection, supporting continuous product development.

Keywords:
Health informaticsInterventionRandomized controlled trialResearchSoftware development

More Related Videos

The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time
06:05

The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

Related Experiment Videos

Last Updated: May 7, 2026

E-Patient Counseling Trial (E-PACO): Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial (E-PACO): Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time
06:05

The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

Area of Science:

  • Digital Health
  • Health Services Research
  • Clinical Trial Methodology

Background:

  • Rigorous evaluation of eHealth interventions is essential but often faces cost and time constraints.
  • Efficient methodologies are needed to support ongoing product development and iteration.
  • Online platforms offer potential for streamlined trial execution.

Purpose of the Study:

  • To describe a pragmatic randomized controlled trial (RCT) for evaluating a web-based eHealth intervention.
  • To demonstrate an approach for efficient and timely evaluation within an intervention's life cycle.
  • To inform product development through continuous empirical input.

Main Methods:

  • A pragmatic randomized controlled trial (RCT) was conducted entirely online.
  • The "Daily Challenge" web-based intervention was evaluated for effectiveness.
  • Participant recruitment and data collection were managed through online platforms.

Main Results:

  • 1,503 participants were recruited in 49 days.
  • Follow-up rates were 68.7% at 30 days and 62.5% at 90 days.
  • Data collection from baseline to 90-day follow-up was completed within 5 months.

Conclusions:

  • Rigorous eHealth intervention trials can be conducted efficiently and in a timely manner.
  • An online, pragmatic RCT approach supports continuous evaluation and product iteration.
  • Leveraging existing resources enables cost- and time-efficient trial execution.