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Updated: May 7, 2026
06:55
Protocol to Create Chronic Wounds in Diabetic Mice
Published on: September 25, 2019
Neoplastic wounds and degenerescence.
S Meaume1, I Fromantin, Luc Teot
1Wound Healing Unit, Geriatric and Dermatologic Center, Hôpital Rothschild, 7, Rue de Santerre, 75012 Paris, France.
Journal of Tissue Viability
|October 1, 2013
Summary
Malignant wounds affect 5-10% of cancer patients, including rare Marjolin's ulcers arising from chronic wounds. Early diagnosis via systematic biopsy of persistent wounds is crucial for managing these rare skin cancers.
Area of Science:
- Oncology
- Dermatology
- Pathology
Background:
- Malignant wounds complicate 5-10% of cancer cases, presenting as invasive skin lesions.
- Marjolin's ulcers are rare malignancies developing in chronic wounds, scars, or inflamed skin.
- These ulcers can transform into squamous cell carcinoma, melanoma, or other cancers.
Purpose of the Study:
- To review the occurrence and characteristics of malignant wounds and Marjolin's ulcers.
- To highlight the association between chronic wounds and secondary malignancies.
- To emphasize the need for improved diagnosis and data collection.
Main Methods:
- Literature review of malignant transformation in chronic wounds.
- Analysis of clinical presentations and associated conditions.
- Discussion of diagnostic criteria and epidemiological gaps.
Main Results:
- Marjolin's ulcers arise from chronic inflammation or scarring, with squamous cell carcinoma being common.
- Specific associations include chronic ulcers, burn scars, and venous insufficiency.
- Epidermoid carcinomas are found in 0.21-0.34% of leg ulcers, but data is limited.
Conclusions:
- Malignant transformation of chronic wounds necessitates clinical vigilance.
- Systematic biopsy of chronically open wounds is recommended for early diagnosis.
- Further epidemiological studies are needed to address data deficiencies.
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