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Polymorphism and solvatomorphism 2009.
1Center for Pharmaceutical Physics, Milford, New Jersey 08848. hbrittain@centerpharmphysics.com.
Journal of Pharmaceutical Sciences
|October 2, 2013
Summary
This review summarizes 2009 research on polymorphism and solvatomorphism, covering crystal structures, preparation, properties, and patents. It highlights advancements in understanding solid-state forms of chemical substances.
Area of Science:
- Solid-state chemistry
- Crystallography
- Materials science
Background:
- Polymorphism and solvatomorphism describe different crystal structures of the same chemical compound.
- Understanding these phenomena is crucial in pharmaceuticals and materials science.
- Annual reviews provide a comprehensive overview of recent advancements.
Purpose of the Study:
- To review and synthesize research published in 2009 concerning polymorphism and solvatomorphism.
- To cover a broad spectrum of studies, from theoretical to practical applications.
- To include relevant US patents issued in 2009.
Main Methods:
- Literature review of major physical, crystallographic, and pharmaceutical journals.
- Inclusion of computational, theoretical, preparative, and characterization studies.
- Analysis of published data on properties, phase transformations, and processing effects.
Main Results:
- A comprehensive summary of 2009 research on crystal systems with identical elemental composition (polymorphism) and those including solvent molecules (solvatomorphism).
- Categorization of studies into general interest, computational, preparative, structural, property-related, and phase transformation aspects.
- Compilation of relevant US patents from 2009.
Conclusions:
- The review provides a valuable snapshot of the state of research in polymorphism and solvatomorphism in 2009.
- It highlights the interdisciplinary nature of solid-state chemistry research.
- The findings underscore the importance of continued investigation into crystal forms for various scientific and industrial applications.
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