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Butyl methoxy dibenzoylmethane.
Jutta Kockler1, Sherryl Robertson, Michael Oelgemöller
1School of Pharmacy and Molecular Science, James Cook University, Townsville, Queensland, Australia.
Summary
This profile details Butyl methoxy dibenzoylmethane (Avobenzone), a common UV filter in sunscreens. It covers its properties, analysis, stability, and toxicity, highlighting its UVA I absorbance and photodegradation susceptibility.
Area of Science:
- Cosmetic Science
- Photochemistry
- Analytical Chemistry
Background:
- Butyl methoxy dibenzoylmethane, commonly known as Avobenzone, is a widely utilized UV filter in sunscreen formulations.
- It primarily absorbs UVA I radiation but is prone to photodegradation, impacting its efficacy and stability in products.
Purpose of the Study:
- To create a comprehensive profile of Butyl methoxy dibenzoylmethane (Avobenzone).
- To document its general information, usage, preparation, physical characteristics, analytical methods, stability, and toxicity.
Main Methods:
- Literature review and data compilation on Avobenzone.
- Analysis of physical characteristics using techniques like DSC, NMR, MS, and X-ray diffractometry.
- Review of analytical methods including chromatography (TLC, GC, HPLC) and compendial assays.
Main Results:
- Detailed characterization of Avobenzone's physical and chemical properties.
- Documentation of various analytical techniques for identification, purity, and assay.
- Information on Avobenzone's photostability, photostabilization strategies, and toxicological data.
Conclusions:
- Butyl methoxy dibenzoylmethane (Avobenzone) is a critical UVA filter with well-defined properties and analytical methods.
- Understanding its photodegradation and stability is essential for effective sunscreen formulation and safety assessment.
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