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Polymorphism and solvatomorphism 2009.

Harry G Brittain¹

¹Center for Pharmaceutical Physics, Milford, New Jersey 08848. hbrittain@centerpharmphysics.com.

Journal of Pharmaceutical Sciences

|October 2, 2013

Summary

This review summarizes 2009 research on polymorphism and solvatomorphism, covering crystal structures, preparation, properties, and patents. It highlights advancements in understanding solid-state forms of chemical substances.

Keywords:

X-ray powder diffractometry crystallography crystals hydrates/solvates polymorphism

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Area of Science:

Solid-state chemistry
Crystallography
Materials science

Background:

Polymorphism and solvatomorphism describe different crystal structures of the same chemical compound.
Understanding these phenomena is crucial in pharmaceuticals and materials science.
Annual reviews provide a comprehensive overview of recent advancements.

Purpose of the Study:

To review and synthesize research published in 2009 concerning polymorphism and solvatomorphism.
To cover a broad spectrum of studies, from theoretical to practical applications.
To include relevant US patents issued in 2009.

Main Methods:

Literature review of major physical, crystallographic, and pharmaceutical journals.
Inclusion of computational, theoretical, preparative, and characterization studies.
Analysis of published data on properties, phase transformations, and processing effects.

Main Results:

A comprehensive summary of 2009 research on crystal systems with identical elemental composition (polymorphism) and those including solvent molecules (solvatomorphism).
Categorization of studies into general interest, computational, preparative, structural, property-related, and phase transformation aspects.
Compilation of relevant US patents from 2009.

Conclusions:

The review provides a valuable snapshot of the state of research in polymorphism and solvatomorphism in 2009.
It highlights the interdisciplinary nature of solid-state chemistry research.
The findings underscore the importance of continued investigation into crystal forms for various scientific and industrial applications.