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Updated: Feb 11, 2026
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In-situ Tapering of Chalcogenide Fiber for Mid-infrared Supercontinuum Generation
Published on: May 27, 2013
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Mid-Infrared Spectroscopy of Pharmaceutical Solids
1Center for Pharmaceutical Physics, Milford, NJ, United States.
Summary
Infrared spectroscopy is a powerful tool for analyzing pharmaceutical solids, revealing details about their solid-state properties, polymorphism, hydrates, and cocrystals. This review covers the technique
Area of Science:
- Pharmaceutical Solid-State Characterization
- Spectroscopic Techniques
- Materials Science
Background:
- Infrared absorption spectroscopy is a well-established method for the physical characterization of pharmaceutical solids.
- Spectra analysis, particularly energy values, provides insights into solid-state properties.
- The technique is valuable for identification, polymorphism studies, hydrate analysis, and cocrystal investigations.
Purpose of the Study:
- To provide a comprehensive overview of the theoretical foundations of infrared spectroscopy.
- To illustrate the practical applications of infrared spectroscopy in pharmaceutical solid-state analysis.
- To highlight the growing importance of FTIR in studying drug substances, hydrates, and cocrystals.
Main Methods:
- Review of theoretical principles underlying infrared absorption spectroscopy.
- Analysis of spectral data to understand solid-state properties.
- Examination of case studies involving drug substances, hydrates, and cocrystals.
Main Results:
- Infrared spectroscopy offers a robust method for identifying pharmaceutical solids.
- Trends in spectral energy values correlate with solid-state properties.
- FTIR is effective for evaluating polymorphism, hydrate water content, and cocrystal systems.
Conclusions:
- Infrared spectroscopy is a versatile and powerful technique for pharmaceutical solid-state characterization.
- The methodology is essential for understanding polymorphism, hydrates, and cocrystals.
- This review provides foundational knowledge and practical examples for applying infrared spectroscopy.
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