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Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model
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Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model

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Targeted therapies in rare sarcomas: IMT, ASPS, SFT, PEComa, and CCS

Silvia Stacchiotti1, Andrea Marrari, Angelo P Dei Tos

  • 1Adult Sarcoma Medical Oncology Unit, Department of Cancer Medicine, Fondazione IRCCS Istituto Nazionale Tumori, via Venezian 1, Milan 20133, Italy.

Hematology/Oncology Clinics of North America
|October 8, 2013
PubMed

Insights

This review examines targeted therapy data for rare soft tissue sarcomas. It covers inflammatory myofibroblastic tumor, alveolar soft part sarcoma, solitary fibrous tumor, PEComa, and clear cell sarcoma.

Area of Science:

  • Oncology
  • Medical Science
  • Rare Cancers

Background:

  • Soft tissue sarcomas (STS) encompass diverse rare subtypes.
  • Limited data exists on targeted therapies for specific rare STS entities.

Purpose of the Study:

  • To review current data on targeted medical treatments for a subgroup of rare soft tissue sarcomas.
  • To consolidate information on treatment efficacy for specific rare STS.

Main Methods:

  • Literature review of available data.
  • Analysis of clinical activity of targeted therapies.

Main Results:

  • Data highlights varying activity of targeted treatments across rare STS.
  • Specific insights into inflammatory myofibroblastic tumor, alveolar soft part sarcoma, solitary fibrous tumor, malignant perivascular epithelioid cell tumor (PEComa), and clear cell sarcoma.

Conclusions:

  • Targeted therapies show potential in specific rare soft tissue sarcomas.
  • Further research is needed to optimize treatment strategies for these rare entities.
Keywords:
Alveolar soft part sarcomaChemotherapyClear cell sarcomaHemangiopericytomaInflammatory myofibroblastic tumorPerivascular epithelioid cell tumorSarcomaSolitary fibrous tumor

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