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Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry
Published on: May 19, 2020
A review of the JR blood group system
Lilian Castilho1, Marion E Reid
1PhD (corresponding author), Professor and Researcher, Hemocentro, Unicamp, Rua Carlos Chagas 480, Campinas, SP, Brazil, 13083-870.
Abstract:
The JR blood group system (ISBT 032) consists of one antigen,Jra, which is of high prevalence in all populations. The rare Jr(a-) phenotype has been found mostly in Japanese and other Asian populations, but also in people of northern European ancestry, in Bedouin Arabs, and in one Mexican. Anti-Jra has caused transfusion reactions and is involved in hemolytic disease of the fetus and newborn. The Jra antigen is located on ABCG2 transporter, a multipass membrane glycoprotein (also known as the breast cancer resistance protein, BCRP), which is encoded by the ABCG2 gene on chromosome 4q22.1. The Jr(a-) phenotype mostly results from recessive inheritance of ABCG2 null alleles caused by frameshift or nonsense changes.
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