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Related Concept Videos

Cholecystitis01:20

Cholecystitis

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Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

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Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
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Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

29
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
29
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

918
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Hepatic Drug Excretion: Enterohepatic Cycling01:17

Hepatic Drug Excretion: Enterohepatic Cycling

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Enterohepatic cycling involves the active secretion of drugs and their metabolites into the bile via transporters in the canalicular membrane of hepatocytes. This secretion is an integral part of the digestive process, releasing these substances into the gastrointestinal (GI) tract.
Post-release drugs and metabolites can be reabsorbed into the body from the intestine. For conjugated metabolites like glucuronides, reabsorption requires enzymatic hydrolysis by intestinal microflora. This...
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Updated: May 7, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
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Drug-induced cholestasis.

Kalyan Ram Bhamidimarri1, Eugene Schiff

  • 1University of Miami, 1500NW 12th Avenue, Suite 1101, Miami, FL 33136, USA.

Clinics in Liver Disease
|October 9, 2013
PubMed
Summary
This summary is machine-generated.

Drug-induced cholestasis can be acute or chronic, potentially leading to cirrhosis. This review covers common culprits, diagnosis, and management strategies for this liver injury.

Keywords:
Bile duct injuryCholestasisDrugsLiver injuryManagement

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Area of Science:

  • Hepatology
  • Toxicology
  • Pharmacology

Background:

  • Drug-induced cholestasis is a significant cause of liver injury, with increasing numbers of implicated agents including pharmaceuticals, herbals, and supplements.
  • Understanding the mechanisms of cholestasis has advanced with research into molecular transporters crucial for bile transport.

Purpose of the Study:

  • To summarize the spectrum of drugs and agents causing drug-induced cholestasis.
  • To outline the diagnostic approaches for drug-induced cholestasis.
  • To provide guidance on the management of drug-induced cholestasis.

Main Methods:

  • Literature review of drug-induced cholestasis.
  • Analysis of recent findings on molecular transporters in bile transport.
  • Synthesis of information on offending agents, diagnosis, and management.

Main Results:

  • The number of drugs and other agents causing cholestatic liver injury is expanding.
  • Molecular transporter research offers insights into drug-induced liver injury patterns and cholestasis mechanisms.

Conclusions:

  • Drug-induced cholestasis presents as acute or chronic liver injury, potentially progressing to duct loss and cirrhosis.
  • This review provides a comprehensive overview of causative agents, diagnostic criteria, and therapeutic strategies for drug-induced cholestasis.