The novel allele HLA-C*03:04:36 identified by sequence-based typing

Area of Science:

• Immunogenetics
• Molecular Biology
• Human Leukocyte Antigen (HLA) System

Background:

• The Human Leukocyte Antigen (HLA) system plays a critical role in immune response.
• Accurate HLA allele identification is crucial for transplantation and disease association studies.
• Continuous discovery of new HLA alleles refines our understanding of immune diversity.

Purpose of the Study:

• To report the discovery and characterization of a novel HLA allele.
• To detail the specific genetic variation differentiating the new allele from a known one.

Main Methods:

• Nucleotide sequencing of the relevant HLA gene region.
• Comparison of the obtained sequence with existing HLA allele databases.

Main Results:

• A new HLA allele, designated HLA-C*03:04:36, was identified.
• This allele differs from HLA-C*03:04:01:01 by a single nucleotide substitution at codon 207 (GGC to GGT).

Conclusions:

• The identification of HLA-C*03:04:36 expands the known HLA-C allele repertoire.
• This finding highlights the ongoing need for comprehensive HLA typing and database updates.