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Published on: August 13, 2019
Alveolar ridge and maxillary sinus augmentation using rhBMP-2: a systematic review
Rubens Moreno de Freitas1, Rubens Spin-Neto, Elcio Marcantonio Junior
1Department of Oral Diagnosis and Surgery - Periodontics, UNESP - Universidade Estadual Paulista, Araraquara Dental School, Araraquara, SP, Brazil; Laboratory for Applied Periodontal & Craniofacial Regeneration, Department of Periodontics and Oral Biology, College of Dental Medicine, Department of Orthopedic Surgery, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA.
Recombinant human bone morphogenetic protein-2 (rhBMP-2) in an absorbable collagen sponge (ACS) carrier shows promise for alveolar ridge and maxillary sinus augmentation. While effective, autogenous bone grafts demonstrated greater bone height in sinus augmentation.
Area of Science:
- Regenerative medicine
- Biomaterials science
- Oral and maxillofacial surgery
Background:
- Alveolar ridge and maxillary sinus augmentation are crucial for dental implant success.
- Autogenous bone grafts are the traditional standard but have limitations.
- Recombinant human bone morphogenetic protein-2 (rhBMP-2) in an absorbable collagen sponge (ACS) carrier offers a potential alternative.
Purpose of the Study:
- To systematically review clinical and safety data of rhBMP-2/ACS for alveolar ridge and maxillary sinus augmentation in humans.
- To evaluate the efficacy of rhBMP-2/ACS compared to traditional methods.
Main Methods:
- Systematic review of clinical studies and case series published from 1980 to June 2012.
- Inclusion criteria: >10 subjects, maxillary sinus or alveolar ridge augmentation (not with implant placement).
Main Results:
- Seven studies met eligibility criteria.
- rhBMP-2/ACS facilitated clinically meaningful bone formation for maxillary sinus augmentation, enabling dental implant placement.
- Autogenous bone grafts resulted in significantly greater bone height (1.6 mm) in sinus augmentation compared to rhBMP-2/ACS.
- rhBMP-2/ACS maintained alveolar ridge height and enhanced width in extraction sockets.
- No significant safety concerns were reported for the intended indications.
Conclusions:
- rhBMP-2/ACS is a promising alternative to autogenous bone grafts for alveolar ridge and maxillary sinus augmentation.
- Further optimization of rhBMP-2/ACS dosage and carrier could enhance its efficacy and clinical applications.
