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Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...
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A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles
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A CMOS enhanced solid-state nanopore based single molecule detection platform.

Chinhsuan Chen, Sukru Yemenicioglu, Ashfaque Uddin

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |October 11, 2013
    PubMed
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    This study introduces a new CMOS platform for solid-state nanopore sensing, overcoming baseline current limitations for label-free detection. The digitally-assisted system enhances DNA translocation analysis and data interpretation.

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    Area of Science:

    • Nanotechnology
    • Electronics Engineering
    • Biophysics

    Background:

    • Solid-state nanopores offer label-free, single-molecule electronic detection.
    • Existing transimpedance stages face dynamic range issues due to steady-state baseline currents.

    Purpose of the Study:

    • To propose a digitally-assisted baseline cancellation CMOS platform for nanopore sensing.
    • To overcome dynamic range limitations in measuring ionic currents through nanopores.

    Main Methods:

    • Development of a CMOS platform with digitally-assisted baseline cancellation.
    • Implementation of auto-zeroing techniques to reduce 1/f noise.
    • Quantitative DNA translocation experiments using a 5nm silicon nitride pore.

    Main Results:

    • The proposed platform tolerates a 10µA steady-state baseline current.
    • Achieved a usable bandwidth of 750kHz.
    • Demonstrated superior performance compared to a commercial system in DNA translocation experiments.

    Conclusions:

    • The digitally-assisted baseline cancellation CMOS platform effectively addresses dynamic range limitations in nanopore sensing.
    • The enhanced system provides unambiguous data interpretation for molecular analysis.
    • This technology advances label-free electronic detection capabilities for single molecules.