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Bluetongue virus-induced interferon in cattle.
American Journal of Veterinary Research
|June 1, 1985
Summary
Bluetongue virus (BTV) infection in calves induced interferon (IFN), crucial for initial antiviral response. However, BTV
Area of Science:
- Veterinary Virology
- Immunology
- Animal Health
Background:
- Bluetongue virus (BTV) is an important animal pathogen.
- Interferon (IFN) plays a critical role in antiviral immunity.
- Understanding BTV's interaction with the host immune system is vital for disease management.
Purpose of the Study:
- To investigate the role of interferon (IFN) in cattle following bluetongue virus (BTV) infection.
- To determine the kinetics of BTV replication and IFN response in inoculated calves.
- To assess the suitability of BTV as a model for inducing circulating IFN in cattle.
Main Methods:
- Calves were intravenously inoculated with bluetongue virus (BTV), serotype 10.
- Serum interferon (IFN) titers and peripheral blood BTV loads were quantified.
- The temporal relationship between IFN detection and viral load was analyzed.
Main Results:
- All inoculated calves developed detectable circulating interferon (IFN) for 2–4 days.
- Highest bluetongue virus (BTV) titers in peripheral blood occurred after serum IFN was no longer detected.
- BTV infection induced neutropenia, potentially increasing susceptibility to secondary infections.
Conclusions:
- Interferon (IFN) is critical for the early antiviral response against bluetongue virus (BTV) in cattle.
- The transient nature of the IFN response compared to persistent BTV suggests limitations in IFN's long-term control.
- Bluetongue virus (BTV) may not be an ideal model for studying circulating IFN induction in cattle due to associated neutropenia.