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Nuclear receptor coactivators: master regulators of human health and disease

Subhamoy Dasgupta1, David M Lonard, Bert W O'Malley

  • 1Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030;

Annual Review of Medicine
|October 12, 2013
PubMed

Insights

Transcriptional coregulators modulate nuclear receptor function. Over 400 identified, their roles in human physiology and disease are increasingly understood, offering new therapeutic targets.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Transcriptional coregulators, including coactivators and corepressors, are key regulators of nuclear receptor and transcription factor activity.
  • Over 400 coregulators have been identified since the discovery of steroid receptor coactivator-1 (SRC-1).
  • Understanding coregulator function is crucial for comprehending human physiology.

Purpose of the Study:

  • To review the advancements in understanding transcriptional coregulators.
  • To highlight the role of SRC family coactivators in gene regulation.
  • To explore therapeutic strategies targeting coactivators for disease intervention.

Main Methods:

  • Literature review of transcriptional coregulator research.
  • Analysis of molecular technologies for characterizing protein complexes.
  • Examination of the SRC family of coactivators and their associations.

Main Results:

  • Deciphering coregulator function has significantly advanced the understanding of human physiology.
  • Deregulated coregulator expression is linked to various diseases and pathologies.
  • Molecular technologies facilitate detailed characterization of SRC coactivator complexes.

Conclusions:

  • Continued discoveries expand knowledge of coactivator roles in human diseases.
  • Novel coactivator-targeting strategies offer potential for therapeutic interventions.
  • Coregulators are pivotal in gene regulation and disease pathogenesis.

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