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Resveratrol: from basic studies to bedside.

Adriana Borriello1, Debora Bencivenga, Ilaria Caldarelli

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Resveratrol, a plant polyphenol, shows potential in modulating cell behavior and treating chronic diseases like diabetes and cancer. Further clinical trials are needed to confirm its effectiveness in humans.

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Area of Science:

  • Natural Product Chemistry
  • Pharmacology
  • Cell Biology

Background:

  • Plants produce numerous natural products with significant biological activities.
  • Resveratrol (3,5,4'-trihydroxystilbene) is a key plant-derived polyphenol known to influence cell phenotypes.
  • Its pleiotropic effects are extensively studied in various cellular and animal models.

Purpose of the Study:

  • To review the diverse biological activities of resveratrol.
  • To assess its potential in managing chronic diseases and cancer.
  • To highlight the need for further clinical investigation.

Main Methods:

  • Literature review of studies on resveratrol's effects.
  • Analysis of data from cellular models, cancer studies, and animal models for chronic diseases.
  • Evaluation of reported toxicity and existing clinical trial data.

Main Results:

  • Resveratrol modulates cell proliferation, differentiation, apoptosis, autophagy, angiogenesis, and inflammation.
  • It demonstrates chemotherapeutic potential against various cancers.
  • Animal studies indicate benefits for type 2 diabetes, obesity, cardiovascular disease, metabolic syndrome, and neurodegenerative disorders.
  • Resveratrol exhibits low toxicity.

Conclusions:

  • Resveratrol possesses a wide range of beneficial biological activities.
  • Its potential in chronic disease management and cancer therapy is promising.
  • Extensive clinical trials are essential to validate these findings in human subjects.