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Updated: May 7, 2026

Controlled Odor Mimic Permeation Systems for Olfactory Training and Field Testing
Published on: January 28, 2021
Use of olfactory training in post-traumatic and postinfectious olfactory dysfunction.
Iordanis Konstantinidis1, Evangelia Tsakiropoulou, Paschalia Bekiaridou
1Smell and Taste Clinic, Second Academic Otorhinolaryngology Department, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Olfactory training using specific odors improved olfactory function in patients with postinfectious and post-traumatic smell loss. This 16-week intervention enhanced smell identification and discrimination compared to controls.
Area of Science:
- Otolaryngology
- Neuroscience
- Sensory Science
Background:
- Olfactory dysfunction can result from infections or trauma.
- Olfactory training (OT) involves repeated odor exposure to improve smell function.
- Effectiveness of OT in specific olfactory dysfunction etiologies requires further investigation.
Purpose of the Study:
- To evaluate the efficacy of a 16-week olfactory training program.
- To assess olfactory function in patients with postinfectious olfactory dysfunction (PIOD) and post-traumatic olfactory dysfunction (PTOD).
- To compare outcomes between patients undergoing olfactory training and control groups.
Main Methods:
- A prospective study involving 119 patients with PIOD and PTOD.
- Patients were divided into olfactory training groups (n=72) and control groups (n=47).
- Olfactory function was assessed using the Sniffin' Sticks test and a visual analogue scale over 16 weeks.
Main Results:
- Olfactory training significantly improved olfactory function scores compared to controls in both PIOD and PTOD groups.
- Improvements were observed in 67.8% of postinfectious and 33.2% of post-traumatic patients.
- Olfactory identification and discrimination showed the most significant improvements.
Conclusions:
- A 16-week olfactory training regimen can enhance olfactory sensitivity in patients with PIOD and PTOD.
- Olfactory training offers a potential therapeutic strategy for smell loss.
- The study highlights the benefits of structured odor exposure for olfactory rehabilitation.
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