Brain natriuretic peptide in acute ischemic stroke
Kenji Maruyama1, Tsuyoshi Shiga2, Mutsumi Iijima1
1Department of Neurology, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
Summary
Elevated brain natriuretic peptide (BNP) levels in acute ischemic stroke patients are linked to coronary artery disease and atrial fibrillation. Higher BNP levels correlate with larger infarcts and worse outcomes.
Area of Science:
- Cardiology
- Neurology
- Biochemistry
Background:
- Elevated serum brain natriuretic peptide (BNP) is linked to cardioembolic stroke, particularly in patients with atrial fibrillation (AF).
- The precise mechanisms driving increased BNP levels in acute ischemic stroke (AIS) remain incompletely understood.
Purpose of the Study:
- To investigate the factors associated with elevated serum BNP levels in patients diagnosed with acute ischemic stroke.
Main Methods:
- Serum BNP levels were measured in 231 adult patients with AIS.
- Stroke subtypes were classified using the Trial of ORG 10172 in Acute Stroke Treatment criteria.
- Correlations were analyzed between BNP levels and various clinical, laboratory, and imaging parameters, including coronary artery disease (CAD), AF, creatinine (Cr), modified Rankin Scale (mRS) score, infarct size, and CHADS2 score.
Main Results:
- Serum BNP levels showed significant correlations with CAD, AF, Cr, mRS, and cardioembolism (CE).
- BNP levels were notably higher in patients with larger infarcts, higher mRS scores at discharge, and elevated CHADS2 scores.
- Among patients with AF, higher BNP levels were associated with larger infarcts and worse functional outcomes.
Conclusions:
- Serum BNP levels are associated with specific stroke etiologies and severity markers in AIS.
- BNP may serve as a potential biomarker for stroke severity and prognosis, particularly in patients with atrial fibrillation.
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