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Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
Published on: December 2, 2022
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Brachytherapy and endoresection for choroidal melanoma: a cohort study
James C Rice1, Clare Stannard, Colin Cook
1Department of Ophthalmology, Groote Schuur Hospital and University of Cape Town, , Cape Town, South Africa.
The British Journal of Ophthalmology
|October 18, 2013
Summary
Endoresection may offer better visual outcomes for medium choroidal melanomas compared to brachytherapy. Further research is needed to confirm recurrence and metastasis rates for endoresection treatments.
Area of Science:
- Ophthalmology
- Oncology
Background:
- Choroidal melanoma is a rare intraocular malignancy.
- Conservative treatment options aim to preserve vision and the eye.
- Brachytherapy and endoresection are established conservative treatments.
Purpose of the Study:
- To compare the outcomes of brachytherapy and endoresection for medium-sized choroidal melanomas.
- To evaluate visual acuity, local recurrence, and metastasis rates between the two treatment modalities.
Main Methods:
- Retrospective cohort study comparing patients treated with brachytherapy and endoresection.
- Medium tumors defined as 2.5-10 mm height and <16 mm diameter.
- Follow-up for visual acuity, local recurrence, enucleation, and metastasis.
Main Results:
- Endoresection patients had thicker tumors and were further from the fovea.
- Visual acuity of 6/18 or better was maintained in 41% of endoresection vs. 35% of brachytherapy patients.
- Endoresection showed a trend towards better final visual acuity (22% higher likelihood >2/60), but local recurrence and metastasis rates were not significantly different.
Conclusions:
- Endoresection may provide superior visual outcomes for selected medium choroidal melanomas.
- Further investigation is warranted for endoresection's impact on local recurrence, enucleation, and metastasis rates.
- Consolidation treatment methods may influence local recurrence rates.
